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目的比较霉酚酸酯与环磷酰胺治疗狼疮性肾炎的临床效果。方法将狼疮性肾炎患者48例根据治疗药物不同分成观察组和对照组各24例。2组患者均应用泼尼松治疗,同时观察组应用霉酚酸酯治疗,对照组应用环磷酰胺治疗。观察2组患者治疗效果,不良反应发生情况:主要包括腹泻、感染、白细胞降低。结果观察组总有效率为75.00%高于对照组的45.83%,不良反应发生率为45.83%低于对照组的70.83%,差异均有统计学意义(P<0.05)。结论采用霉酚酸酯治疗狼疮性肾炎疗效较显著,优于环磷酰胺,不仅提高了患者的生命质量,且安全性高,在临床上可推广应用。
Objective To compare the clinical efficacy of mycophenolate mofetil and cyclophosphamide in the treatment of lupus nephritis. Methods Forty-eight patients with lupus nephritis were divided into observation group (24 cases) and control group (24 cases) according to different therapeutic drugs. Both groups were treated with prednisone, while the observation group was treated with mycophenolate mofetil and the control group with cyclophosphamide. Observation of two groups of patients with treatment, adverse reactions occurred: mainly diarrhea, infection, leukopenia. Results The total effective rate was 75.00% in the observation group, 45.83% in the control group, and 45.83% in the control group, which was lower than 70.83% in the control group. The difference was statistically significant (P <0.05). Conclusion The treatment of lupus nephritis with mycophenolate mofetil is more effective than cyclophosphamide, which not only improves the quality of life of patients, but also has high safety and can be widely applied in clinic.