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目的:观察呋塞米联合地塞米松雾化治疗支气管哮喘、慢性阻塞性肺病(COPD)急性期的临床效果。方法:选取2014年1月-2016年6月期间医院内支气管哮喘及COPD急性期患者共100例为研究对象,根据不同治疗方式将病例分为观察组60例、对照组40,两组均给予常规对症治疗,对照组常规对症治疗同时加地塞米松雾化治疗,观察组则在对照组基础上联合地塞米松雾化治疗。结果:观察组患者的急性期缓解时间、抗菌药使用剂量和时间均优于对照组,(P<0.05)。在治疗后、治疗后2周时,观察组患者的PaCO_2、PaO_2、FEV1/FVC、CRP水平均优于对照组(P<0.05)。结论 :呋塞米联合地塞米松经氧驱动雾化治疗支气管哮喘、COPD急性期能快速改善症状,炎症指标、肺功能指标良好改善,安全可靠。
Objective: To observe the clinical effect of furosemide combined with dexamethasone atomization in the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) in acute phase. Methods: A total of 100 patients with bronchial asthma and acute exacerbation of COPD in hospital from January 2014 to June 2016 were selected as study objects. According to different treatment methods, the patients were divided into observation group (60 cases) and control group (40 cases) Conventional symptomatic treatment, control group conventional symptomatic treatment plus dexamethasone atomization treatment, the observation group was treated with dexamethasone atomization on the basis of the control group. Results: The acute phase of remission time and the dosage and time of antimicrobial agents in observation group were better than those in control group (P <0.05). PaCO_2, PaO_2, FEV1 / FVC and CRP levels in observation group were better than those in control group (P <0.05) after treatment and 2 weeks after treatment. Conclusion: Furosemide combined with dexamethasone is effective in the treatment of bronchial asthma by aerosol-driven atomization. The acute phase of COPD can rapidly improve the symptoms and the indexes of inflammation, and the indexes of pulmonary function are well improved and safe and reliable.