c-fos是编码核内蛋白的原癌基因,在基因转录调控中起重要作用。c-fos在细胞及生物体中的表达随增龄而发生变化,被认为是一种衰老相关基因。视交叉上核(suprachiasmaticnuclear,SCN)与下丘脑、松果腺一起被称为哺乳动物生物节律钟,而松果腺分泌的褪黑素(melatonin,MEL)已成为衰老研究领域的研究热点。目前SCN内c-fos基因表达状况以及MEL对其表达状况的影响的研究正在为 c-fos is a proto-oncogene encoding the nuclear protein and plays an important role in gene transcription regulation. The expression of c-fos in cells and organisms changes with age, and is considered as an aging-related gene. The suprachiasmatic nucleus (SCN), together with the hypothalamus and pineal gland, is called the circadian clock of mammals. Melatonin (MEL) secreted by the pineal gland has become a research hotspot in the field of aging research. The current status of c-fos gene expression in SCN and the effect of MEL on its expression status is