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目的:观察盐酸氨溴索注射液治疗慢性支气管炎急性发作的临床疗效。方法:该组80例为医院2010年10月-2014年12月收治的慢性支气管炎急性发作期患者,随机分为治疗组和对照组各40例。对照组给予抗感染、祛痰镇咳、解痉平喘等常规治疗,治疗组在常规治疗基础上加用盐酸氨溴索注射液30mg+5%葡萄糖(或生理盐水)注射液250ml静脉滴注,2次/d,疗程7~10d。观察咳嗽、咳痰情况,肺部啰音变化情况,体温恢复情况等。结果:治疗组显效11例(27.50%),有效26例(65.00%),无效3例(7.50%),总有效率92.50%;对照组显效7例(17.50%),有效23例(57150%),无效10例(25.00%)。两组疗效比较,差异有统计学意认(P<0.05)。两组治疗期间均未出现明显不良反应,临床用药安全。结论:在常规抗感染、祛痰镇咳、解痉平喘基础上加用盐酸氨溴索注射液治疗慢性支气管炎急性发作临床疗效确切,且用药安全性好,值得临床推广应用。
Objective: To observe the clinical efficacy of ambroxol hydrochloride injection in the treatment of acute exacerbation of chronic bronchitis. Methods: The group of 80 patients were admitted to the hospital from October 2010 to December 2014 in patients with acute exacerbation of chronic bronchitis, were randomly divided into treatment group and control group of 40 cases. Control group were given anti-infective, expectorant antitussive, antispasmodic and asthma and other conventional treatment, the treatment group on the basis of conventional treatment plus ambroxol 30mg + 5% glucose (or saline) injection 250ml intravenous infusion, 2 Times / d, treatment 7 ~ 10d. Observation of cough, expectoration, pulmonary rales changes, body temperature recovery and so on. Results: The effective rate of the treatment group was 11 cases (27.50%), 26 cases (65.00%) were effective, 3 cases (7.50%) were ineffective and the total effective rate was 92.50% ), Invalid in 10 cases (25.00%). The difference between the two groups was statistically significant (P <0.05). No significant adverse reactions occurred in both groups during the treatment period, and the clinical medication was safe. Conclusion: In the conventional anti-infective, expectorant antitussive, antispasmodic and asthma based on the addition of ambroxol hydrochloride injection in the treatment of acute exacerbation of chronic bronchitis clinical curative effect, and medication safety is good, worthy of clinical application.