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目的探讨万可松联合呼吸机辅助呼吸治疗6例顽固性癫痫持续状态患者的疗效。方法对于采用常规抗癫痫治疗12h后无效的顽固性癫痫持续状态的6例患者,均应用静脉注射万可松联合气管切开、呼吸机辅助呼吸治疗7~15d以控制癫痫发作。结果6例患者癫痫发作症状得到明显控制,药物起效时间3~6h,停药后平均自动转复时间为30~60min;疗程中未出现与治疗相关的呼吸、循环功能障碍,患者均安全出院。结论万可松联合呼吸机辅助呼吸治疗顽固性癫痫持续状态是安全、有效、可行的。
Objective To investigate the curative effect of metoprolol combined with ventilator-assisted ventilation on 6 patients with intractable status epilepticus. Methods Six patients with intractable status epilepticus that were inactive after 12 h of conventional antiepileptic therapy were treated with intravenous injection of venom combined with tracheotomy and ventilator assisted breathing for 7-15 days to control the seizure. Results The symptoms of epileptic seizures in 6 patients were obviously controlled. The onset time of drugs was 3 ~ 6h. The mean auto-recovery time was 30-60min after stopping drug treatment. No respiratory-circulatory dysfunction occurred during treatment, patients were discharged safely . Conclusion Vancomsone combined with ventilator-assisted respiration in the treatment of persistent status epilepticus is safe, effective and feasible.