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目的探讨血清热应激蛋白70(HSP70)和肿瘤坏死因子α(TNF-α)表达水平与宁夏回汉民族原发性高血压(EH)发病的关系。方法按照纳入与排除标准,从2011年10月至2012年10月期间在宁夏医科大学附属医院和吴忠市人民医院进行健康检查以及在内分泌科住院的人群中,选择229例无血缘关系的原发性高血压患者为病例组,600例无血缘关系的健康人为对照组。结果 EH组血清HSP70表达水平明显高于对照组(P<0.05)。调整性别、年龄和民族因素后,HSP70高水平人群EH的发病风险是低水平人群的2.163倍。HSP70表达水平与收缩压(SBP)呈正相关(P<0.001),与舒张压(DBP)无相关性(P<0.05),TNF-α表达水平与SBP、DBP均呈正相关(均P<0.05)。回汉民族间血清TNF-α表达水平差异均有统计学意义(均P<0.05)。不同TNF-α表达水平间SBP、DBP水平差异均有统计学意义(均P<0.05)。结论血清HSP70表达水平与原发性高血压发病密切相关,随着HSP70表达水平的增高,EH的发病风险也明显增高;TNF-α表达水平可能是原发性高血压的危险因素,也可能与种族遗传有关。
Objective To investigate the relationship between the expression of heat stress protein 70 (HSP70) and tumor necrosis factor α (TNF-α) and the incidence of essential hypertension (EH) in Hui and Han nationalities in Ningxia. Methods According to inclusion and exclusion criteria, from October 2011 to October 2012 in Ningxia Medical University Hospital and Wuzhong People’s Hospital for medical examination and in the endocrinology hospitalization, the selection of 229 cases of unrelated primary Hypertensive patients in the case group, 600 unrelated healthy controls. Results The serum level of HSP70 in EH group was significantly higher than that in control group (P <0.05). After adjusting for gender, age and ethnicity, the risk of EH in high HSP70 population was 2.163 times of that in low population. The expression of HSP70 was positively correlated with SBP (P <0.001) and DBP (P <0.05). The expression of TNF-α was positively correlated with SBP and DBP (all P <0.05) . There were significant differences in serum TNF-α levels between Hui and Han nationality (all P <0.05). There were significant differences in the levels of SBP and DBP between different TNF-α levels (all P <0.05). Conclusion The expression of HSP70 is closely related to the pathogenesis of essential hypertension. With the increase of the expression of HSP70, the risk of EH is also significantly increased. The expression of TNF-α may be the risk factor of essential hypertension, Genetic related.