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分离早孕妇女蜕膜CD56~+NK样细胞,采用改进的乳酸脱氢酶(LDH)释放试验,比较蜕膜与外周血NK细胞杀伤活性。结果发现:蜕膜NK样细胞杀伤活性低于孕妇外周血及正常育龄妇女外周血NK细胞。提示妊娠早期蜕膜局部NK细胞活性受到抑制,可能有利于滋养细胞侵袭和胎盘形成。
The decidual CD56 ~ + NK-like cells in early pregnant women were isolated, and the improved lactate dehydrogenase (LDH) release test was used to compare the NK cell killing activity between decidua and peripheral blood. The results showed that the cytotoxic activity of decidual NK-like cells was lower than that of peripheral blood of pregnant women and normal women of childbearing age. Prompt decidual early decidual NK cell activity was inhibited may be conducive to trophoblast invasion and placental formation.