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我们曾临床观察显示:消渴康片有降低空腹与餐后血糖的功效,有降低甘油三酯及升高高密度脂蛋白胆固醇作用,对多食、多尿、疲乏无力等主要症状改善明显,且无毒副反应。试验研究显示:消渴康片有明显降低高血糖大鼠空腹及餐后血糖作用,对血清胰高血糖素和胰岛素影响不明显,有明显改善血液流变学作用,且呈良好的量一效关系;胰腺组织 HE 染色及免疫组化染色可见其有保护β细胞作用;降低甘油三酯和升高高密度脂蛋白的作用与临床一致;可显著的升高血清 SOD,增加清除自由基能力。基于以上研究结果,本文将重点观察其对大鼠肝细胞内线粒体的作用,从而探讨其作用机理。
Our clinical observations showed that Xiaokekang Tablets have the effects of reducing fasting and postprandial blood glucose, reducing triglycerides and increasing high-density lipoprotein cholesterol, and significantly improving the symptoms of multiple foods, polyuria, fatigue, and weakness. And no toxic side effects. Experimental studies showed that Xiaokekang Tablets significantly reduced fasting and postprandial blood glucose levels in hyperglycemic rats, had no significant effect on serum glucagon and insulin, and significantly improved hemorheology, showing good effect. Relationship; HE staining and immunohistochemical staining of pancreas showed that it protects β cells; the effect of reducing triglycerides and increasing high-density lipoprotein is consistent with clinical practice; serum SOD can be significantly increased, and the ability to scavenge free radicals can be increased. Based on the above research results, this article will focus on its effect on mitochondria in rat liver cells, so as to explore its mechanism of action.