以 ABC 法研究胃癌和相关病变中,胃癌单克隆抗体相应抗原的特征和分布。MGd_1抗原在胃癌阳性率最高,早期胃癌阳性率为80%,进展期胃癌为90%;而胃癌相关病变阳性率较低,癌旁胃粘膜阳性率为45%,胃溃疡边缘异型增生为20%。MG_7抗原在非癌组织中阳性率最低,对胃癌特异性高。MGd_1和 MG_7联合使用,进展期胃癌阳性率达95%,正常粘膜均为阴性。提示单克隆抗体检查对胃癌的诊断和“高危”癌前状态的确定有所帮助。 The ABC method was used to study the characteristics and distribution of the corresponding antigens of gastric cancer monoclonal antibodies in gastric cancer and related lesions. The positive rate of MGd_1 antigen in gastric cancer was the highest. The positive rate of early gastric cancer was 80%, and that of advanced gastric cancer was 90%. The positive rate of gastric cancer-related lesions was low, the positive rate of paragastric mucosa was 45%, and the dysplasia of gastric ulcer was 20%. . The MG_7 antigen has the lowest positive rate in non-cancerous tissues and has a high specificity for gastric cancer. Combined use of MGd_1 and MG_7, the positive rate of advanced gastric cancer was 95%, and normal mucosa was negative. It is suggested that the monoclonal antibody test is helpful in the diagnosis of gastric cancer and the determination of “high risk” precancerous conditions.