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[目的]分析对比应用细胞电脑扫描计算机辅助细胞学检测系统(CCT)、液基细胞学检查计算机辅助细胞学检测系统(LCT)及DNA定量细胞学检测3种方法对诊断宫颈上皮内瘤变(CIN)的意义。[方法]分别采用CCT、LCT及DNA定量细胞学检测,对宫颈细胞学异常者或有临床异常者,行阴道镜下活检。对比3种细胞学检测方法的CIN检出率。[结果]CCT和LCT检测与阴道镜下活检病理结果符合率对比,差异有显著性。LCT和DNA定量细胞学检测与阴道镜下活检病理结果符合率对比,差异无显著性。[结论]LCT和DNA定量细胞学检测由于采用液基薄层制片,较CCT常规宫颈涂片,明显降低假阴性率,并提高了对低度鳞状上皮以上病变的诊断率。DNA定量细胞学可测定DNA含量的改变及检出DNA倍体异常细胞。定期检测可对病变的性质及发展趋势作出客观估计和预测。
[Objective] To analyze and compare the diagnostic methods of cervical intraepithelial neoplasia (CIN) using three methods of computerized cytology detection system (CCT), liquid-based cytology (LCT) and DNA quantitative cytology CIN) meaning. [Methods] CCT, LCT and DNA quantitative cytology were used to detect colposcopic biopsy in patients with abnormal cervical cytology or with clinical abnormalities. The CIN detection rates of three cytological methods were compared. [Results] The coincidence rates of CCT, LCT and colposcopic biopsy were significant. LCT and DNA quantitative cytology and biopsy biopsy results consistent with the rate of contrast, no significant difference. [Conclusion] LCT and DNA quantification cytology test significantly reduce the false negative rate and improve the diagnosis of lesions above the low grade squamous epithelium due to the liquid - based lamellar preparation compared with the conventional cervical smear. Quantitative cytology of DNA can detect changes in DNA content and detect DNA ploidy abnormal cells. Regular testing can make objective estimates and predictions of the nature and trends of the disease.