近年来化妆品的功能性层出不穷,随之带来化妆品不良反应的报道屡见不鲜,让广大爱美消费者对特殊用途化妆品的安全性提出了质疑,因此化妆品上市前的安全性评价尤为重要。急性经皮毒性试验可以考察化妆品对整个机体功能、生理及生化水平的影响,是评价化妆品及外用透皮制剂安全性不可或缺的方法[1-3]。水飞蓟宾防晒霜是由黑龙江某机构研制的,具 Cosmetics in recent years, an endless stream of functionality, followed by reports of adverse reactions of cosmetics are commonplace, so that the majority of consumers love the beauty of cosmetics for specific safety questioned, so cosmetics safety assessment before listing is particularly important. Acute dermal toxicity test can examine the cosmetic effects on the function, physiology and biochemistry of the whole body. It is an indispensable method to evaluate the safety of cosmetic and topical transdermal preparations [1-3]. Silybin sunscreen is developed by a body in Heilongjiang Province, with