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目的:观察外源性肺表面活性物质(PS)治疗糖尿病孕妇新生儿呼吸窘迫综合征(NRDS)的疗效。方法:将28例糖尿病孕妇NRDS分成PS组13例和非PS组15例,PS组在机械通气及常规治疗同时使用PS,非PS组仅予机械通气及常规治疗,比较两组新生儿的治疗效果。结果:使用PS治疗后,PS组新生儿OI持续下降、a/A PO2、VEI持续升高,与治疗前比较差异有统计学意义(P<0.01),同比非PS组差异有统计学意义(P<0.01);PS组机械通气、用氧和住院时间显著少于非PS组,差异有统计学意义(P<0.05)。结论:PS治疗能有效地改善糖尿病孕妇NRDS病例的肺顺应性及氧合功能,缩短机械通气、用氧及住院时间。
Objective: To observe the therapeutic effect of exogenous pulmonary surfactant (PS) on neonatal respiratory distress syndrome (NRDS) in diabetic pregnant women. Methods: The NRDS of 28 pregnant women with diabetes were divided into PS group (n = 13) and non-PS group (n = 15). In PS group, PS was used in both mechanical ventilation and routine treatment. Non-PS group was given only mechanical ventilation and routine treatment. effect. Results: After PS treatment, the newborn infants in PS group continued to decline, a / A PO2 and VEI continued to increase, with statistical significance (P <0.01), the difference was statistically significant P <0.01). The mechanical ventilation, oxygen use and hospital stay in PS group were significantly less than those in non-PS group (P <0.05). Conclusion: PS treatment can effectively improve the lung compliance and oxygenation function of NRDS cases in diabetic pregnant women and shorten the duration of mechanical ventilation, oxygen and hospital stay.