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目的:探讨宁膝1号治疗膝关节骨性关节炎的作用机制。方法:将受试大鼠随机分为5组,即正常组、模型组、筋骨痛消丸组、宁膝1号低剂量组、宁膝1号高剂量组,后4组以木瓜蛋白酶和半胱氨酸混合液关节腔注射建立骨关节炎动物模型,后3组按规定给药3周,各组分别测定SOD和NO,并取下膝关节作病理组织学检查。结果:宁膝1号低、高剂量组可明显升高SOD活力,降低NO含量;病理组织学显示宁膝1号低、高剂量组对骨关节滑膜及软骨的损伤、周围软组织炎症均有减轻,程度与筋骨痛消丸相似。结论:宁膝1号对大鼠骨关节炎有一定的治疗作用,其作用机制与升高SOD活力,降低NO含量有关。
Objective: To investigate the mechanism of the treatment of knee osteoarthritis with Ningshao 1. Methods: Rats were randomly divided into 5 groups: normal group, model group, Jinu Tongxiao Pill group, Ning Keng No. 1 low dose group, and Ning Knee No. 1 high dose group. The latter 4 groups were papain and half. An animal model of osteoarthritis was established by intraarticular injection of cystine mixed solution. The last three groups were administered for 3 weeks as required. SOD and NO were measured in each group, and the knee joint was removed for histopathological examination. Results: The low and high dose group of Ningshou No. 1 can significantly increase the activity of SOD and reduce the content of NO. Histopathology showed that the low and high doses of Ning Keng No. 1 had synovial and cartilage damage and inflammation of the surrounding soft tissues. The degree of relief is similar to that of Jin Gu Tong Xiao Wan. Conclusion: Ningshen 1 has a certain therapeutic effect on osteoarthritis in rats. Its mechanism of action is related to the increase of SOD activity and decrease of NO content.