血管活性因子与药物性肾病（Ｄｒｕｇ－ＩｎｄｕｃｅｄＮｅｐｈｒｏｐａｔｈｙＤＩＮ）的关系成为近年人们关注的焦点之一，研究表明内皮素、一氧化氮、腺苷、心钠素、前列腺素等内源性血管活性物质介导或参与ＤＩＮ的血液动力学异常。 Vascular activity factor and drug-induced nephropathy (Drug-Induced NephropathyDIN) has become the focus of attention in recent years, studies have shown that endothelin, nitric oxide, adenosine, atrial natriuretic peptide, prostaglandins and other endogenous vasoactive substances mediated Or participate in hemodynamic abnormalities at DIN.