在人群横断面研究基础上,用低、中、高三种钙水平分别干预、追踪妊娠大鼠和孕期妇女。发现,低钙供给时妊娠母体钙吸收率显著增加,保证了胎儿的体格发育,是母体对低钙的适应,但母体骨钙减少、骨密度降低,妊娠危险因素增加;传统低钙膳食+奶粉40g/d可部分改善骨密度,传统低钙膳食+奶粉40g/d+钙600mg/d,钙摄入达1274.6±147.8mg/d可维持母体骨密度致正常水平,此可视为钙的适宜推荐量;母体雌激素水平与钙摄入量显著负相关,推测雌激素分泌增加促进了钙的吸收及婴儿对钙的利用;母体骨钙素水平与钙摄入量及骨密度显著正相关,推测充足钙供给促进了骨钙素的分泌,并因此增加了母体的骨密度,雌激素、骨钙素参与孕期机体对低钙摄入的适应性调节。该系列研究全面系统地阐明了孕期钙代谢及其调节、钙适宜需要量、钙干预等热点问题。 Based on the population cross-sectional study, interventions were performed with low, medium and high calcium levels to track pregnant rats and pregnant women. Found that low calcium diet significantly increased maternal calcium absorption rate to ensure the physical development of the fetus is the maternal adaptation to low calcium, but the mother bone calcium decreased bone mineral density decreased risk factors increased; traditional low-calcium diet + milk powder 40g / d can partially improve the bone mineral density, the traditional low calcium diet + milk powder 40g / d + calcium 600mg / d, calcium intake up to 1274.6 ± 147.8mg / d can maintain the normal level of the mother’s bone mineral density, which can be regarded as the recommended calcium The level of maternal estrogen was significantly negatively correlated with calcium intake, suggesting that increased estrogen secretion promoted the absorption of calcium and the utilization of calcium in infants. There was a significant positive correlation between maternal serum osteocalcin and calcium intake and bone mineral density Adequate calcium supply promotes the secretion of osteocalcin, and thus increases the mother’s bone density, estrogen, osteocalcin in adaptive regulation of low calcium intake during pregnancy. This series of research comprehensively and systematically expounded the hot issues of calcium metabolism during pregnancy and its regulation, calcium requirements, calcium intervention.