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X半抗原是从人乳中分离出来的一种半抗原物质,在人类的正常上皮组织中含量甚微,但在肿瘤组织中的含量显著增加。因此,文献上称X半抗原为一种肿瘤相关性抗原。我们用单克隆抗体ABC免疫酶标组化法,观察胃食管癌及慢性萎缩性胃炎X半抗原的表达状况,拟从肿瘤相关抗原表达方面进一步了解慢性萎缩性胃炎与胃癌发病间的关系。 材料和方法 从胃镜检查中取得胃粘膜组织128例,其中经病理活检诊断为胃癌者43例,食管癌14例,慢性萎缩性胃炎32例,浅表性胃炎12例,胃粘膜大致正常27例。 组织立即放入0.015M PBS中洗去血渍,经
The X hapten is a hapten substance isolated from human milk that contains very little in human normal epithelial tissue but has a significant increase in tumor tissue content. Therefore, the X hapten is referred to in the literature as a tumor-associated antigen. We used the monoclonal antibody ABC immunohistochemistry method to observe the expression status of gastroesophageal cancer and chronic atrophic gastritis X hapten. We intend to further understand the relationship between chronic atrophic gastritis and the pathogenesis of gastric cancer from the aspect of tumor-associated antigen expression. Materials and Methods 128 cases of gastric mucosal tissue were obtained from gastroscopy. Among them, 43 were diagnosed as gastric cancer by pathological biopsy, 14 were esophageal cancer, 32 were chronic atrophic gastritis, 12 were superficial gastritis, and 27 were normal gastric mucosa. . The tissue was immediately put into 0.015M PBS to wash away blood stains.