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目的:观察胃欣颗粒对炎症的影响。方法:分别采用大鼠慢性胃炎模型,二甲苯引起小鼠耳肿胀模型及大鼠塑料环肉芽肿试验模型,观察胃欣颗粒对实验性胃炎、炎症的影响。结果:胃欣颗粒可使慢性胃炎模型大鼠的胃表层粘膜修复,粘液细胞逐渐减少或消失,使慢性胃炎所固有的腺上皮变性、萎缩、肠上皮化生等病理改变消失;对二甲苯引起的小鼠耳肿胀和对大鼠塑料环肉芽生长有一定抑制作用。结论:胃欣颗粒具有一定的抗炎作用,对慢性胃炎有明显的治疗作用。
Objective: To observe the effect of Weixin Granule on inflammation. METHODS: Rat chronic gastritis models, xylene-induced mouse ear swelling model and rat plastic ring granuloma test model were used to observe the effect of Weixin Granule on experimental gastritis and inflammation. RESULTS: Weixin granules could repair the gastric epithelium mucosa of rats with chronic gastritis, and the mucous cells gradually decreased or disappeared, and the pathological changes such as glandular epithelial degeneration, atrophy, and intestinal metaplasia that were inherent in chronic gastritis disappeared; and paraxylene caused The ear swelling of the mouse and the inhibition of the granulation growth of the rat plastic rings were somewhat inhibited. Conclusion: Weixin Granules have certain anti-inflammatory effects and have obvious therapeutic effects on chronic gastritis.