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我们采用链脲佐菌素(Streptozotocin)在Wistar大鼠中建立了糖尿病模型,并对糖尿病的发生机制作了初步探讨。 实验方法:Wistar雌性大鼠50只(中国医科院实验动物研究所提供),体重250±50g。实验组(30只)给予链脲佐菌素(美国Sigma公司生产)65mg/kg腹腔注射。注射后24～72小时动物出现多饮、
We used streptozotocin (Streptozotocin) to establish a diabetic model in Wistar rats, and made a preliminary study of the pathogenesis of diabetes. Methods: Fifty Wistar female rats (provided by Institute of Experimental Animals, Chinese Academy of Medical Sciences) weighing 250 ± 50g. Experimental group (30) given streptozotocin (Sigma, USA) 65mg / kg intraperitoneal injection. 24 to 72 hours after injection animals appear to drink more,