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目的分析前列腺特异性抗原(PSA)、移行带前列腺特异性抗原密度(PSA-TZ)、前列腺特异性抗原密度(PSAD)在前列腺穿刺活检中的诊断意义。方法 112例前列腺穿刺活检患者,观察病理结果 ,检测血清总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)、前列腺体积(PV)、PSA,计算FPSA/TPSA(F/T)、PSAD、PSA-TZ,比较良恶性患者相关指标的差异。结果 112例患者经前列腺穿刺后病理诊断明确,良性前列腺增生患者81例,前列腺癌患者31例。良性前列腺增生患者与前列腺癌患者年龄比较,差异无统计学意义(t=0.59,P>0.05),PV、PSA、FPSA、F/T、PSAD、PSA-TZ比较,差异具有统计学意义(t=4.69、2.75、2.13、2.40、4.68、4.69,P<0.05)。结论联合运用PSAD、PSA-TZ可以提高前列腺穿刺阳性率,同时为再次穿刺提供指导。
Objective To analyze the diagnostic significance of prostate-specific antigen (PSA), prostate-specific antigen density (PSA-TZ) and prostate-specific antigen density (PSAD) in prostatic biopsy. Methods One hundred and twelve prostatic biopsy specimens were collected and the pathological results were observed. The levels of total prostate specific antigen (TPSA), free prostate specific antigen (FPSA), prostate volume (PV), PSA and FPSA / TPSA PSAD, PSA-TZ, the difference between benign and malignant patients relevant indicators. Results The pathological diagnosis of 112 patients was confirmed by prostatic puncture. There were 81 patients with benign prostatic hyperplasia and 31 patients with prostate cancer. There was no significant difference in age between patients with benign prostatic hyperplasia and those with prostatic cancer (t = 0.59, P> 0.05), and there was significant difference between PV, PSA, FPSA, F / T, PSAD and PSA-TZ = 4.69,2.75,2.13,2.40,4.68,4.69, P <0.05). Conclusions The combined use of PSAD and PSA-TZ can increase the positive rate of prostate biopsy and provide guidance for puncture again.