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目的探讨白细胞计数与代谢综合征(MS)及其相关因素:肥胖、血压、血糖、血脂之间的关联。方法选取中国人民解放军第三〇九医院2012年1~12月体检人群中白细胞(WBC)≤10.0×109/L的11 526人为研究对象,其中男性7 244人,年龄(43.57±12.77)岁,女性4 282人,年龄(45.05±13.24)岁。用Spearman相关分析研究WBC与MS相关组分之间的关联性,并将研究对象按照WBC四分位数法分4组(WBC 1~4组,即从WBC最低到最高组),进行多因素logistic回归,分析随WBC计数水平的升高MS患病风险的变化。结果 MS组人群的WBC[(7.07±1.44)×109/L]明显高于未患MS组人群[(6.43±1.49)×109/L],差异有统计学意义(P<0.01);在Spearman两变量相关分析和控制了年龄及MS其他组分后的偏相关分析中,WBC计数与MS组分中的体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、低密度脂蛋白(LDL)、甘油三酯(TG)均呈正相关(P<0.05),与高密度脂蛋白(HDL)均呈负相关(P<0.01);多因素logistic回归分析显示,在调整了年龄、性别、LDL、胆固醇(TC)后,WBC水平的升高与MS发病风险的增加呈正相关,与第1组(WBC最低组)比较,第2、3、4组OR值分别为1.193、1.733、2.356。结论 WBC与MS及其组分间存在相关性,可作为MS发病的一个预测指标。
Objective To investigate the correlation between leukocyte count and metabolic syndrome (MS) and its related factors: obesity, blood pressure, blood glucose, blood lipids. Methods A total of 11 526 white blood cells (WBC) ≤ 10.0 × 109 / L from the 309th Hospital of People’s Liberation Army from January to December in 2012 were selected as subjects, including 7 244 males, aged 43.57 ± 12.77 years, There were 4,282 women aged 45.05 ± 13.24 years old. Spearman correlation analysis was used to investigate the correlation between WBC and MS-related components. Subjects were divided into four groups according to WBC quartile (WBC 1-4 group, from WBC lowest to highest group) Logistic regression was used to analyze changes in the prevalence of MS with increasing WBC count levels. Results The WBC [(7.07 ± 1.44) × 109 / L] in MS group was significantly higher than that in MS group [(6.43 ± 1.49) × 109 / L, P <0.01) Two-variable correlation analysis and control of age and other components of MS after partial correlation analysis, WBC count and MS components in the body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FPG (P <0.05), but negatively correlated with high density lipoprotein (HDL) (P <0.01). Multivariate logistic regression analysis showed that, After adjusted for age, sex, LDL and cholesterol (TC), the increase of WBC level was positively correlated with the increase of the risk of MS. Compared with the first group (WBC lowest group), OR of the second, third and fourth group were respectively 1.193, 1.733, 2.356. Conclusion There is a correlation between WBC and MS and its components, which can be used as a predictor of MS.