间变大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)是一种临床少见且异质性明显的恶性肿瘤,约占成人非霍奇金淋巴瘤的3%及儿童淋巴瘤的10%~15%~([1-2])。1985年Stein等~([3])首先将一组高表达CD30(Ki-1)、以大细胞增殖为主的淋巴瘤命名为ALCL。Morris等~([4])发现了ALCL中最常见的染色体异常t(2;5)(p23;q35),即2号染色体上的间变淋巴瘤激酶(ALK)基因和5号染色体上的核磷蛋白基因融合产生了融合基因NPM-ALK。根据ALK蛋白的表达状态,可将 Anaplastic large cell lymphoma (ALCL) is a rare and heterogenous malignancy that accounts for approximately 3% of adult non-Hodgkin’s lymphomas and 10% to 15% of childhood lymphomas. ~([1-2]). In 1985 Stein et al. [3] first named a group of lymphomas with high expression of CD30 (Ki-1) and predominant cell proliferation as ALCL. Morris et al. ([4]) found the most common chromosomal abnormality t(2;5) (p23;q35) in ALCL, ie the intergenic lymphoma kinase (ALK) gene on chromosome 2 and chromosome 5 Fusion of the nuclear phosphoprotein gene resulted in the fusion gene NPM-ALK. According to the expression state of ALK protein,