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沉默信息调节因子2(Silent Information Regulator2,SIR2)是依赖于烟酰胺腺嘌呤二核苷酸(Nicotin Amide Adenine Dinucleotide,NAD)的第三类组蛋白去乙酰化酶,SIRT1是与哺乳动物Sir2同源性最高的家族成员,不仅使组蛋白去乙酰化以介导基因沉默,在心血管系统,还可能与FOXO家族、NF-κB、PARP-1、PGC-1、PPAR-γ、eNOS等多种靶基因或蛋白相互作用,对细胞生存、衰老、炎症和氧化应激等起到十分重要的调节作用。本文拟对SIRT1在心血管系统调节氧化应激、凋亡、衰老方面的主要下游作用靶基因、蛋白以及目前其在心脏/血管保护方面的研究进展进行综述。
Silent Information Regulator 2 (SIR2) is a type III histone deacetylase dependent on Nicotin Amide Adenine Dinucleotide (NAD), which is homologous to mammalian Sir2 The most familial members of the family not only deacetylate histone to mediate gene silencing but also in the cardiovascular system and may also interact with multiple targets such as the FOXO family, NF-κB, PARP-1, PGC-1, PPAR-γ, eNOS Gene or protein interaction, on cell survival, aging, inflammation and oxidative stress play a very important regulatory role. This review aims to summarize the major downstream target genes and proteins of SIRT1 in cardiovascular regulation of oxidative stress, apoptosis and aging, as well as their current advances in cardiac / vascular protection.