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目的研究急性冠脉综合征(ACS)早期应用辛伐他汀对血脂、缺血事件发生的影响,使人们了解他汀类药物在ACS中的作用及强化降脂的意义。方法60例ACS患者被随机分为对照组(N=30)和治疗组(N=30),用辛伐他汀治疗(20mg口服,每晚一次,疗程60天),观察用药前后血脂、缺血事件的发生情况。结果对照组治疗前后血脂无显著变化(P>0.05)。与对照组相比,治疗组用药后血脂明显下降(P<0.05)。缺血事件发生率明显下降(X2=4.68,P<0.05)。两组治疗前后肝、肾功能,肌酸磷酸激酶水平均无明显变化。结论ACS早期应用辛伐他汀可明显降低缺血事件发生率。
Objective To study the effect of early application of simvastatin on the incidence of blood-lipid and ischemic events in patients with acute coronary syndrome (ACS), so as to make people understand the role of statins in ACS and enhance the significance of lipid-lowering. Methods Sixty ACS patients were randomly divided into control group (N = 30) and treatment group (N = 30). Simvastatin (20mg orally, once a night for 60 days) was used to observe the changes of blood lipid, ischemia The occurrence of the incident. Results Before and after treatment, there was no significant change in blood lipids in the control group (P> 0.05). Compared with the control group, the treatment group after administration of blood lipids decreased significantly (P <0.05). The incidence of ischemic events decreased significantly (X2 = 4.68, P <0.05). Before and after treatment, liver and kidney function, creatine phosphokinase level had no significant changes. Conclusions Early application of simvastatin can significantly reduce the incidence of ischemic events.