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目的:观察丙谷双肽在晚期食管贲门癌化疗过程中对化疗不良反应、机体功能以及客观疗效的影响。方法:将48例晚期食管贲门癌患者随机分为化疗+丙谷双肽组(研究组,24例)和化疗组(对照组,24例),观察两组的不良反应、体质量改变和客观疗效。结果:研究组和对照组口腔黏膜炎、恶心/呕吐、腹泻以及体质量减轻差异均有统计学意义,P值分别为0.016、0.023、0.033和0.042。而两组客观有效率差异无统计学意义,P=0.551。结论:丙谷双肽可减少晚期食管贲门化疗所致的口腔黏膜炎、恶心/呕吐及腹泻发生率,并能改善患者的机体功能,同时不降低化疗疗效。
Objective: To observe the effects of valproate on adverse reactions, body function and objective curative effect of chemotherapy in the treatment of advanced esophageal and cardiac cancer. Methods: Forty-eight patients with advanced esophageal and cardiac cancer were randomly divided into chemotherapy plus valproate (24 in study group) and chemotherapy group (24 in control group). Adverse reactions, changes in body mass and objectivity Efficacy. Results: There were significant differences in oral mucositis, nausea / vomiting, diarrhea and weight loss between the study group and the control group, with P values of 0.016, 0.023, 0.033 and 0.042, respectively. There was no significant difference in objective efficiency between the two groups, P = 0.551. CONCLUSION: CG can reduce the incidence of oral mucositis, nausea / vomiting and diarrhea caused by advanced esophageal and cardial chemotherapy, and can improve the body function of patients without reducing the curative effect of chemotherapy.