［目的］观察顺铂联合足叶乙甙联合治疗恶性胸腔积液的治疗效果。［方法］先将胸水尽量抽尽，将顺铂５０ｍｇ，足叶乙甙１００ｍｇ溶于生理盐水５０ｍｌ，胸腔内缓慢注射。［结果］６０例病人中，ＣＲ４４例，ＰＲ９例，总有效率８８．３％。［结论］顺铂联合足叶已甙胸腔化疗治疗恶性胸腔积液有效率高，毒副反应轻，是值得推广的疗法。 [Objective] To observe the effect of combined treatment of cisplatin and etoposide on malignant pleural effusion. [Methods] The pleural effusion was drained as much as possible. 50 mg of cisplatin and 100 mg of acetylcholine were dissolved in 50 ml of normal saline and injected slowly into the chest cavity. [Results] Of the 60 patients, 44 were CR and 9 were PR. The total effective rate was 88.3%. [Conclusion] Cisplatin combined with thoracic cavity chemotherapy for the treatment of malignant pleural effusion has high efficiency and mild toxicity. It is worthy of promotion.