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目的 探讨乳癌患者单纯手术和化疗再手术后血清可溶性白介素Ⅱ受体水平对预后的临床意义。方法 采用双抗体酶联免疫吸附法对 5 0例正常人、5 0例乳癌单纯手术患者与 68例乳癌化疗再手术患者血清可溶性白介素Ⅱ (SIL 2R)水平进行了测定。结果 乳癌患者血清SIL 2R显著高于正常人 (P <0 .0 1) ,单纯手术后和化疗 3周再手术后患者血清SIL 2R水平分别为 ( 5 2 6.5 2± 2 45 .77)U/ml与( 4 3 2 .14± 167.3 6)U/ml。两种治疗方法差异有显著性 (P <0 .0 5 )。结论 提示乳癌患者化疗后再手术切除对预后有十分重要的意义。
Objective To investigate the clinical significance of serum soluble interleukin-receptor II levels in patients with breast cancer after surgery and chemotherapy. Methods The levels of serum soluble interleukin II (SIL 2R) in 50 normal individuals, 50 breast cancer patients and 68 breast cancer patients undergoing chemotherapy were measured by double antibody enzyme-linked immunosorbent assay. Results Serum SIL 2R was significantly higher in breast cancer patients than in normal controls (P < 0.01). Serum SIL 2R levels after surgery alone and after 3 weeks of chemotherapy were (5 2 6.5 2 ± 2 45 .77) U/ Ml and (4 3 2 .14± 167.3 6) U/ml. There was a significant difference between the two treatments (P < 0.05). Conclusion It suggests that surgical resection after chemotherapy in breast cancer patients is of great significance for prognosis.