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给大鼠气管内一次滴注猪胰弹性蛋白酶三个月内可形成肺动脉高压。本文探讨当归能否防治这类肺动脉高压。实验用雄性Wistar大鼠,开始体重130～180g,分四组:1.胰弹性蛋白酶组(n=22),气管内一次滴注猪胰弹性蛋白酶(100μ/100g BW,0.1ml)形成肺动脉高压动物模型。2.当归一次治疗组(n=11),气管内滴酶液后当即腹腔内一次注入0.5ml当归提取液(1.25g/100g BW)。3.当归五次治疗组(n=8)滴酶液后连续五天每天注一次当归。4.对照组(n=6),气管内一次滴注等量生理盐水。滴酶液后三个月
Pulmonary arterial hypertension can be established within three months after intratracheal instillation of porcine pancreatic elastase. This article discusses whether Angelica can control this kind of pulmonary hypertension. The experimental male Wistar rats were started weighing 130-180 g and divided into four groups: 1. Pancreatic elastase group (n=22), intratracheal instillation of porcine pancreatic elastase (100μ/100g BW, 0.1 ml) to form pulmonary hypertension Animal model. 2. In the treatment group (n=11), when the endotracheal drops the enzyme solution, 0.5 ml of Angelica sinensis extract (1.25 g/100 g BW) was injected once intraperitoneally. 3. Angelica was injected once a day for five consecutive days after dropping the enzyme solution in five treatment groups (n=8). 4. In the control group (n=6), an equal amount of saline was instilled into the trachea. Three months after the enzyme solution