应用血管内导管作心内膜—心肌活体组织检查作为诊断心脏疾患的辅助手段,已有二十年历史。在克山病患者身上作该项检查,除日本学者有1例的经验外,国内以本组病例为首次;病人的右心室心内膜—心肌组织作了光镜和电镜检查,本文报告光镜检查结果。材料和方法本组包括同一病区(陕西省旬邑县内)的8例克山病人,临床诊断为潜在型者2例,慢型6例。其中男性3例,女性5例;年龄从20—47岁;除1例为学生外其余7例均为农民。由于每例病人取材1—3次不等,8例病人共检查组织15小块。组织取下后立即固定在10%福尔马林液中,作常规石蜡包埋。因每次取出的组织块体积较小(从1/3粒小米大到0.3×0.2×0.2厘米),故每颗组织块均作了全部连续切片,除一般作HE染色外,有的切片尚作了van Gieson染色法、Mallory染色法和Masson三色染色法。 Endovascular endocardium-myocardial biopsy has been used as an adjunct to diagnosis of heart disease for more than 20 years. In Keshan disease patients who made this examination, in addition to the Japanese scholars have one case of experience, the domestic first case of this group of patients; patients with right ventricular endocardium - myocardial tissue made by light microscopy and electron microscopy, this report light Mirror examination results. Materials and Methods This group includes 8 cases of Keshan patients in the same ward (in Xunyi County, Shaanxi Province). There are 2 cases of potential diagnosis and 6 cases of chronic type. There were 3 males and 5 females, ranging in age from 20 to 47 years old; the remaining 7 were peasants except 1 student. As each patient taken 1-3 times range, 8 patients were examined tissue 15 small pieces. Tissue removed immediately fixed in 10% formalin, for routine paraffin embedding. Due to the smaller volume of tissue removed each time (from 1/3 millet to 0.3 × 0.2 × 0.2 cm), so each piece of tissue made all the serial sections, in addition to the general HE staining, and some slices Van Gieson staining, Mallory staining and Masson trichrome staining were performed.