细胞因子信号转导抑制子(suppressor of cytokine signalling,SOCS)蛋白和CISs(cytokine-inducible SRC homology 2(SH2)-domain-containing proteins)包括了一组细胞内蛋白家族,已证明能调节细胞对细胞因子的反应[1～4]。大部分的SOCS蛋白被细胞因子诱 The suppressor of cytokine signaling (SOCS) proteins and CISs (cytokine-inducible SRC homology 2 (SH2) -domain-containing proteins) include a family of intracellular protein families that have been shown to regulate cell-to- Factors of response [1 ~ 4]. Most of the SOCS proteins are induced by cytokines