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探讨欣普贝生用于足月妊娠胎膜早破促宫颈成熟及引产的有效性及安全性。方法:对90例胎膜早破、Bishop宫颈评分<6分、无妊娠合并症、单胎、头位并要求阴道试产的初产妇,选50例阴道放置欣普贝生促宫颈成熟作为研究组,另选40例同样条件的初产妇用催产素促宫颈成熟作为对照组。比较两组孕妇的Bishop评分变化、临产情况及分娩的发生时间、感染率、剖宫产率、对胎儿及新生儿的影响。结果:研究组孕妇给药后,24h后39例直接进入产程,其余7例Bishop评分提高≥2分。而对照组仅14例进入产程,9例Bishop评分提高≥2分,两组比较,差异有统计学意义(P<0.01)。研究组从给药到临产的时间平均为6h40min,对照组平均为11h15min,两组比较,差异有统计学意义(P<0.05)。研究组的剖宫产率为14%,而对照组则为35%。结论:欣普贝生可安全、有效地用于足月胎膜早破引产。
To investigate the efficacy and safety of Enbubese for gestational premature rupture of the cervix to promote cervical ripening and induction of labor. Methods: 90 cases of premature rupture of membranes, Bishop cervical score <6 points, no complications of pregnancy, single fetus, head position and require vaginal trial of primiparous women, selected 50 cases of vaginal placement of Xin Pibei cervical ripening as a study Group, another 40 cases of the same conditions of primipara with oxytocin promote cervical maturation as a control group. The changes of Bishop score, labor status, delivery time, infection rate, cesarean section rate, fetus and newborn in both groups were compared. Results: In the study group, 39 pregnant women directly entered the labor process after 24 hours of administration, and the remaining 7 patients had a Bishop score ≥2 points. The control group only 14 cases into the labor process, 9 cases of Bishop score increased ≥ 2 points, the two groups, the difference was statistically significant (P <0.01). The average time from administration to labor was 6h40min in the study group and 11h15min in the control group. The difference between the two groups was statistically significant (P <0.05). The study group cesarean section rate was 14%, while the control group was 35%. Conclusions: Enbupton is safe and effective for term premature rupture of membranes.