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目的血液灌流不同治疗次数对百草枯中毒的临床效果。方法 79例百草枯中毒患者随机分为治疗组39例与常规组40例,两组患者入院后给予洗胃、导泻、吸附、糖皮质激素、免疫抑制剂及护肝肾等综合治疗,在此基础上,治疗组与对照组采用不同的血液灌流治疗方案。观察两组的治疗效果。结果 8周后治疗组治愈23例,治愈率为59%,对照组治愈14例,治愈率为35%,两组比较差异有统计学意义(P<0.05);血液灌流后两组患者的肝酶、心肌酶显著下降,差异具有统计学意义(P<0.05),治疗组的酶学变化明显低于对照组,差异具有统计学意义(P<0.05);治疗组动脉血二氧化碳分压(Pa CO2)未进行性降低,动脉血氧分压(Pa O2)显著高于对照组,差异具有统计学意义(P<0.05)。结论血液灌流可降低百草枯对脏器的损害,治疗总时间20 h的血液灌流治疗方案,可以明显降低百草枯中毒的病死率。
Objective To study the clinical effect of different times of hemoperfusion on paraquat poisoning. Methods A total of 79 patients with paraquat poisoning were randomly divided into treatment group (n = 39) and routine group (n = 40). Patients in both groups were given gastric lavage, cathartic absorption, glucocorticoid, immunosuppressive agents, On this basis, the treatment group and control group using different hemoperfusion regimens. Observed the treatment effect of two groups. Results After 8 weeks, 23 cases were cured in the treatment group, the cure rate was 59%, the control group was cured in 14 cases, the cure rate was 35%, the difference between the two groups was statistically significant (P <0.05) (P <0.05). The changes of enzymology in the treatment group were significantly lower than those in the control group (P <0.05). The arterial partial pressure of carbon dioxide (Pa (P <0.05). The PaO2 was significantly higher than that of the control group (P <0.05). Conclusion Hemoperfusion can reduce paraquat damage to organs, and the treatment of hemoperfusion with total time of 20 h can significantly reduce the mortality of paraquat poisoning.