目的探讨经阴道子宫输卵管动态三维超声造影评价输卵管通畅性的有效性和安全性。方法对125例不孕患者,采用SonoVue造影剂,进行动态三维超声造影,记录相关指标,其中35例结果与腹腔镜通染液试验(CLP)进行对照,评价动态三维超声造影评估输卵管通畅性的有效性和安全性。结果 125例患者共计242条输卵管,超声造影结果显示输卵管通畅88条,输卵管通而不畅84条,输卵管阻塞70条。动态三维超声造影诊断输卵管阻塞的敏感度为92.00%、特异度93.33%、阳性预测值88.46%、阴性预测值95.45%、阳性似然比13.8,阴性似然比0.086。一致性分析显示,两种方法高度一致,Kappa值为0.846;125例患者造影过程中不同程度腹痛发生率为96%;术后阴道出血持续时间为(1.21±0.30)d,所有病例术后无阴道感染发生。结论动态三维超声造影评价输卵管通畅性具有较高的有效性和安全性,可作为临床评价输卵管通畅性的筛查方法之一。 Objective To investigate the efficacy and safety of transvaginal uterine tubal dynamic three-dimensional contrast-enhanced ultrasound in the evaluation of tubal patency. Methods 125 cases of infertility patients with SonoVue contrast agent, dynamic three-dimensional contrast echocardiography, recording the relevant indicators, of which 35 cases with laparoscopic-staining test (CLP) were compared to evaluate dynamic three-dimensional contrast echocardiography assessment of tubal patency Effectiveness and safety. Results 125 patients a total of 242 tubal, ultrasound showed 88 tubal patency, tubal obstruction 84, tubal obstruction 70. The sensitivity and accuracy of dynamic three - dimensional contrast - enhanced ultrasound in diagnosis of tubal occlusion were 92.00%, 93.33%, 88.46%, 95.45%, respectively. The positive likelihood ratio was 13.8 and the negative likelihood ratio was 0.086. Consistency analysis showed that the two methods were highly consistent, with a Kappa value of 0.846. The incidence of abdominal pain was 96% in 125 patients with different degrees of angiography and the duration of postoperative vaginal bleeding was (1.21 ± 0.30) d. All patients had no postoperative Vaginal infection occurs. Conclusions Dynamic three-dimensional contrast-enhanced ultrasound in the evaluation of tubal patency has high efficacy and safety, which can be used as a screening method for clinical evaluation of tubal patency.