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采用免疫组织化学ＬＳＡＢ法，对５４例肾细胞癌作了增殖细胞核抗原（ＰＣＡＮ）和Ｐ５３蛋白表达的研究。结果表明：ＰＣＮＡ阳性反应计算出的增殖指数（ＰＩ）在肾细胞癌Ⅰ、Ⅱ级与Ⅲ、Ⅳ级之间有显著性差异；Ｐ５３蛋白阳性１０例（１８．３％），而正常对照组无１例阳性；ＰＣＮＡ所表示的ＰＩ与Ｐ５３蛋白阳性表达呈正相关，认为ＰＣＮＡ的表达是评估肾细胞癌预后的有用指标，Ｐ５３蛋白可作为肾细胞癌的一个恶性依据。
Immunohistochemical LSAB method was used to study the expression of proliferating cell nuclear antigen (PCAN) and P53 protein in 54 cases of renal cell carcinoma. The results showed that the proliferation index (PI) calculated by PCNA positive reaction was significantly different between grade Ⅰ, Ⅱ and Ⅲ, Ⅳ of renal cell carcinoma; P53 protein was positive in 10 cases (18.3%), while the normal control group No positive results were found in one case. The expression of PCNA was positively correlated with the positive expression of P53 protein. The expression of PCNA was considered as a useful index to evaluate the prognosis of renal cell carcinoma. P53 protein could be used as a malignant basis of renal cell carcinoma.