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长期使用非甾类抗炎药(NSAIDs)在60～70％病人可引起小肠炎症。摄入NSAIDs后数小时,小肠的通透性即增加,细菌这时容易侵入产生炎症。本文研究葡萄糖和枸橼酸盐对消炎痛所引起肠通透性增加的保护作用。方法:生物利用度的测定:12名受试者随机双盲交叉分组,一组给予50mg消炎痛,另一组给予消炎瘾复合制剂(消炎痛:葡萄糖:枸橼酸=1:15:15),内含消炎痛50 mg,随后测定血浆消炎痛浓度。通透性试验:20名受试者随机分组泓定肠道通透性:1.对照组;2.服用消炎痛125mg组;3.服用葡萄糖-枸橼酸-消炎痛复合制剂组(15:15:1),内含消炎痛125mg。另外也用了葡萄糖-枸橼酸-消炎痛复合制
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) in 60 to 70% of patients can cause inflammation of the small intestine. A few hours after ingestion of NSAIDs, the permeability of the small intestine is increased, and the bacteria are easily invaded and inflamed at this time. This article studies the protective effects of glucose and citrate on increased indomethacin-induced intestinal permeability. METHODS: Bioavailability was measured in 12 subjects in a randomized double-blind crossover study, with one group receiving indomethacin 50 mg and the other group being given an anti-inflammatory supplement (indomethacin: glucose: citrate = 1: 15: 15) , Containing indomethacin 50 mg, followed by determination of plasma indomethacin concentration. Permeability test: Twenty subjects were randomly assigned to receive gonadotropin permeability: 1. Control group; 2. Group taking 125 mg of indomethacin; 3. Group taking glucose- citrate-indometacin complex (15: 15: 1), containing indomethacin 125mg. Also used glucose - citric acid - indomethacin compound system