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In this study,we employed a nonthermal atmospheric pressure plasma (NTAPP) jet to evaluate the effect of plasma treatment on the durability of resin-dentin bonding under a thermocycling challenge.Furthermore,we assessed the degradation resistance of plasma-treated collagen under a sodium hypochlorite (NaC10) challenge.We assessed the beneficial effect of NTAPP treatment on the acid-etched dentin-bonding interface by testing the micro-tensile bond strength and examining the morphology.We found that the immediate bonding strength of the dentin significantly increased after NTAPP treatment.Compared with the control group,NTAPP resulted in a more prominent effect on the bonding durability of the dentin-adhesive interface after treatment for 5 or 10 s.Simultaneously,the mechanical strength of dentin collagen under the NaClO challenge was improved.Our results indicate that,in optimal conditions,NTAPP could be a promising method to protect dentin collagen and to improve the bonding durability between dentin and etch-and-rinse adhesives.