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目的:探讨卵巢肿瘤组织中细胞增殖指标Ki67和细胞黏附分子CD24的表达及其与临床病理指标的相关性,为卵巢肿瘤的诊治提供参考依据。方法:采用免疫组织化学SP法检测卵巢肿瘤共97例,良性卵巢上皮性肿瘤14例,交界性卵巢上皮性肿瘤20例,恶性卵巢上皮性肿瘤63例中Ki67和CD24的表达,并评价其与临床病理指标的关系。结果:卵巢良性上皮性肿瘤ki指数>40者有4例,CD24阳性者3例;交界性肿瘤ki指数>40者有9例,CD24阳性者11例;卵巢癌ki指数>40者有49例,CD24阳性者51例;三组比较,差异有统计学意义(P<0.01);Ⅲ～Ⅳ期卵巢癌ki指数为>40者有35例,CD24阳性者35例,显著高于Ⅰ～Ⅱ期卵巢癌中的ki指数>40者17例和CD24阳性者16例,差异有统计学意义(P<0.01);中低分化癌ki指数>40者有32例,CD24阳性者31例,显著高于高分化癌中的ki指数>40者20例和CD24阳性者20例,差异有统计学意义(P<0.05或P<0.01);卵巢癌ki指数,CD24表达与组织类型、淋巴结转移无关,差异无统计学意义(P>0.05);卵巢癌中CD24的阳性表达与ki指数>40的病例数呈正相关。结论:卵巢癌中Ki67,CD24表达显著高于卵巢良性和交界性肿瘤,可作为鉴别良恶性肿瘤的指标;其表达与卵巢癌的临床分期、病理分级有关。
OBJECTIVE: To investigate the expression of Ki67 and CD24 in ovarian tumor and its correlation with clinicopathological parameters, and to provide a reference for the diagnosis and treatment of ovarian tumors. Methods: Immunohistochemical SP method was used to detect the expression of Ki67 and CD24 in 97 cases of ovarian tumors, 14 cases of benign ovarian epithelial tumors, 20 cases of borderline ovarian epithelial tumors and 63 cases of malignant ovarian epithelial tumors, Clinical and pathological indicators of the relationship. Results: There were 4 cases with ki index> 40 and 3 cases with CD24 positive in ovarian benign epithelial tumors, 9 cases with ki index> 40 in borderline tumors, 11 cases with CD24 positive and 49 cases with ovarian cancer ki index> 40 (P <0.01). There were 35 cases with stage Ⅲ-Ⅳ ovarian cancer with ki index> 40 and 35 cases with CD24 positive stage, which were significantly higher than those with stage Ⅰ ~ Ⅱ There were 17 cases with ki index> 40 in 40 cases and 16 cases with CD24 positive in stage ovarian cancer (P <0.01), 32 cases with ki index> 40 in moderately differentiated carcinoma and 31 cases with CD24 positive (P <0.05 or P <0.01). There was no significant difference between ki index and CD24 expression in ovarian cancer and the type of tissue and lymph node metastasis , The difference was not statistically significant (P> 0.05). The positive expression of CD24 in ovarian cancer was positively correlated with the number of cases with ki index> 40. Conclusion: The expression of Ki67 and CD24 in ovarian cancer is significantly higher than benign and borderline ovarian tumors, which can be used as an index to distinguish benign and malignant tumors. The expression of Ki67 and CD24 is correlated with the clinical stage and pathological grade of ovarian cancer.