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目的 研究血管紧张素转换酶 (ACE)基因多态性与血脂及血浆纤维蛋白原 (Fg)之间的相关关系。方法 对 12 6例冠心病、高血压病患者和 6 6例健康对照者分别进行 ACE基因多态性和血脂(包括 CH、TG、HDL - c、L DL - c)、Fg浓度测定 ,分析 ACE基因多态性与血脂及 Fg之间的关系。结果 (1)疾病组 DD基因型频率和 D等位基因频率较正常对照组明显增高 (P<0 .0 1) ;(2 )疾病组 CH、TG、L DL - c、Fg水平明显高于对照组 (P<0 .0 5 ) ,而 HDL - c水平明显低于对照组 (P<0 .0 5 )。且疾病组中ACE基因 DD型者与 ID、II型者间相比差异有显著性 (P <0 .0 5 ) ;(3) ACE基因多态性与 CH、TG、L DL - c及 Fg浓度间呈显著正相关 (r值分别为 0 .6 71,0 .70 2 ,0 .6 83,0 .6 5 3,P值均 <0 .0 1) ;与 HDL - c浓度间存在显著负相关 (r=- 0 .6 4 8,P<0 .0 0 1)。结论 ACE基因 DD型和 D等位基因与血脂代谢异常及血浆 Fg有关 ,而与 等位基因无关。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and plasma lipids and plasma fibrinogen (Fg). Methods ACE gene polymorphisms and serum lipids (including CH, TG, HDL - c, L DL - c) and Fg concentrations were measured in 126 patients with coronary heart disease and hypertension and 66 healthy controls. The levels of ACE Relationship between gene polymorphism and serum lipids and Fg. Results (1) The frequencies of DD genotype and D allele in the disease group were significantly higher than those in the normal control group (P <0.01); (2) The levels of CH, TG, L DL - c and Fg in the disease group were significantly higher than those in the control group Control group (P <0.05), while HDL - c level was significantly lower than the control group (P <0.05). There was a significant difference between ID group and type II among DD genotypes (P <0.05). (3) There was no significant difference between ACE genotype and CH, TG, L DL - c and Fg There was a significant positive correlation between concentration and concentration of HDL - c (r = 0.671, 0.702, 0.638, 0.663, P <0.01) Negative correlation (r = - 0.648, P <0.001). Conclusion The DD genotypes and D allele of ACE gene are related to dyslipidemia and plasma Fg but not to allele.