葡萄糖调节蛋白75(glucose regulated protein75,grp75)是一种主要存在于细胞线粒体中的热休克蛋白(heat shock protein,HSP)[1]。它行使分子伴侣的功能,协助细胞质中合成的线粒体蛋白肽链转运入线粒体,帮助肽链在线粒体中正确折叠和装配,介导异常蛋白质的降解[2]。本文对grp75生物学功能的研究现状作一概述。1grp75的生物学特性 Glucose regulated protein 75 (grp75) is a heat shock protein (HSP) mainly present in mitochondria of cells [1]. It functions as a chaperone and assists in the transport of the mitochondrial protein peptide chain synthesized in the cytoplasm into the mitochondria, helping the peptide chain to properly fold and assemble in mitochondria and mediate the degradation of abnormal proteins [2]. This article gives an overview of the current research on the function of GRP75. 1grp75 biological characteristics