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本文报告我院1980年以来收治确诊的7例急性骨髓纤维化(AMF)。对此组病人:6例用康力龙、硝酸一叶萩碱和强的松,疗效差,均在确诊后0.5～3月内死亡,总病程小于1年(1～10个月)。4例死于感染(肺炎3例,败血症1例),2例死于出血(DLC 1例,上消化道出血1例)。最近1例我们用诱导分化剂维甲酸治疗,病情缓解,一年后信访,恢复良好。AMF诊断一般参照Bearman等提出的标准:1.急性起病,迅速进展的临床过程;2.外周血呈全
This article reports 7 cases of acute myelofibrosis (AMF) admitted to our hospital since 1980. For this group of patients: 6 cases of KangLongLong, monosodium nitrate and prednisone, poor curative effect, all died within 0.5 ~ 3 months after diagnosis, the total duration of less than 1 year (1 ~ 10 months). 4 died of infection (3 cases of pneumonia, 1 case of sepsis) and 2 died of hemorrhage (1 case of DLC and 1 case of upper gastrointestinal bleeding). In the recent case, we used inducing differentiation agent retinoic acid to treat the disease and alleviate it. After a year’s petition, we recovered well. AMF diagnosis generally refer to Bearman and other proposed standards: 1. acute onset, the rapid progress of clinical course; 2. peripheral blood were all