活化的人血浆蛋白C具有抗凝和促纤溶功能,人血浆蛋白S是活化蛋白C,使其发挥生理效应必要的辅因子。1977年Discipio首先在美国西雅图(Seattle)从人血浆中分离出此蛋白,因此命名为蛋白S。1980年,Wa1ker提出蛋白S是一种维生素K依赖性蛋白,并揭示了其生理功能。蛋白S的理化特性和化学结构理化特性人血浆蛋白S系单链糖蛋白。其分子内含有10个γ羧基谷氨酸,3个β羟基天门冬氨酸和7.8%的碳水化合物。其 Activated human plasma protein C has anticoagulant and fibrinolytic functions and human plasma protein S is a cofactor necessary for activating protein C to exert its physiological effects. In 1977, Discipio first isolated this protein from human plasma in Seattle, USA, and named it protein S. In 1980, Wa1ker proposed that protein S is a vitamin K-dependent protein and reveals its physiological function. Physical and chemical properties of protein S and its chemical structure Physical and chemical properties Human plasma protein S is a single chain glycoprotein. Its molecule contains 10 γ carboxyglutamate, 3 β-hydroxy aspartate and 7.8% carbohydrates. its