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目的 探讨维甲酸纳米粒混悬剂对兔眼实验性增生性玻璃体视网膜病变 (PVR)的预防作用。 方法 新西兰白兔 20只(40眼),随机分为 2组:对照组、用药组各 20眼。行气体压迫玻璃体手术 3d后,所有兔眼玻璃体腔内注入2×105个成纤维细胞,再分别注入BSS平衡盐溶液或 17 894mg/L的维甲酸纳米粒混悬剂 0 2mL。以间接检眼镜观察玻璃体混浊情况, 4周后剖开眼球观察视网膜脱离发生情况。 结果 在术后 1、4、7、14、21、28d,对照组分别有 12、14、14、16、20、20眼发生了玻璃体增殖;用药组分别有 9、10、10、11、12、13眼发生了玻璃体增殖,有统计学意义 (P<0 05 )。第 28d病理检查对照组 20眼中 18眼(90% )发生了视网膜脱离,用药组 20眼中 4眼(20% )发生了视网膜脱离,具有统计学意义(P<0 01)。 结论 维甲酸纳米粒混悬剂能有效地预防增生性玻璃体视网膜病变的发生。
Objective To investigate the preventive effect of retinoic acid nanoparticles on rabbit experimental ocular proliferative vitreoretinopathy (PVR). Methods Twenty New Zealand white rabbits (40 eyes) were randomly divided into two groups: the control group and the medication group, 20 eyes each. After 3 days of vitreous oppression, 2 × 105 fibroblasts were injected into the vitreous cavity of all rabbits, and BSA balanced salt solution or 0.2 ml of 17 894 mg / L ATRA nanoparticle suspension was injected into the vitreous cavity respectively. Vitreous opacities were observed with indirect ophthalmoscope. Four weeks later, the eyeballs were dissected to observe the occurrence of retinal detachment. Results At the 1st, 4th, 7th, 14th, 21st, 28th day after operation, vitreous proliferation occurred in 12, 14, 14, 16, 20 and 20 eyes respectively in the control group. , 13 eyes had vitreous proliferation, with statistical significance (P <0 05). Retinal detachment occurred in 18 eyes (90%) in 20 eyes of the 28th day of the pathological examination, and retinal detachment occurred in 4 eyes (20%) of 20 eyes in the medication group, with statistical significance (P <0.01). Conclusion Tretinoin nanoparticle suspension can effectively prevent the occurrence of proliferative vitreoretinopathy.