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目的:观察心复平对药物诱发大鼠实验性心律失常的影响。方法:将Wi St ar大鼠随机分为对照组、普罗帕酮组及心复平大、中、小剂量组,每组10只,各组连续给予预防性治疗1周,末次给药30分钟后,制备乌头碱及氯化钡诱发的大鼠实验性心律失常模型,记录每组大鼠出现室性早搏(VPB)、室性心动过速(VT)、室颤(VF)及死亡(CA)或心律失常恢复的时间。结果:心复平可明显对抗乌头碱及氯化钡诱发的大鼠心律失常,其特点是提高乌头碱致大鼠出现VPB、VT、VF和CA的剂量;推迟氯化钡致大鼠发生VPB和VT的时间并缩短大鼠心律失常的持续时间。结论:心复平对实验性心律失常具有较好的拮抗作用,且有一定的量效关系。
Objective: To observe the effect of Xinfuping on drug-induced experimental arrhythmia in rats. Methods: Wi Star rats were randomly divided into control group, propafenone group and Xinfuping large, medium and small dose group, 10 rats in each group. The rats in each group were given prophylactic treatment for 1 week and the last administration for 30 minutes After the preparation of aconitine and barium chloride-induced experimental arrhythmia model rats were recorded ventricular premature beats (VPB), ventricular tachycardia (VT), ventricular fibrillation (VF) and death CA) or arrhythmia recovery time. Results: XFX can obviously antagonize aconitine and barium chloride-induced arrhythmia in rats, which is characterized by increasing the dose of VPB, VT, VF and CA induced by aconitine in rats; delaying barium chloride-induced rats VPB and VT occur and shorten the duration of arrhythmia in rats. Conclusion: Xinfuping has a good antagonistic effect on experimental arrhythmia, and has a certain dose-effect relationship.