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继发于肝硬化的血小板减少症是晚期肝病患者的常见并发症。其原因可能与脾肿大引起的血小板池容量增加有关。肝硬化患者的血小板相关IgG(PA-IgG)水平增高,提示免疫因素导致的血小板破坏增加可能在血小板减少症的发病机制中起辅助作用。作者以往的研究表明普萘洛尔可使肠系膜上动脉循环血管收缩,因此,推测普萘洛尔可通过对脾动脉循环的类似效应,改善血小板减少症。本研究目的为检验此假说。
Thrombocytopenia secondary to cirrhosis is a common complication of advanced liver disease. The reason may be related to the increased capacity of platelet pool caused by splenomegaly. Platelet-associated IgG (PA-IgG) levels are elevated in patients with cirrhosis, suggesting that an increase in platelet damage caused by immune factors may play a supporting role in the pathogenesis of thrombocytopenia. Previous studies by the authors indicate that propranolol causes vasoconstriction in the superior mesenteric artery, and therefore prophylaxis is that propranolol improves thrombocytopenia by a similar effect on the splenic artery circulation. The purpose of this study is to test this hypothesis.