正交设计法优选跌打促愈片的水提工艺

来源 :中国医院药学杂志 | 被引量 : 0次 | 上传用户:zdnumber
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目的:优选跌打促愈片的提取工艺。方法:以丹酚酸B含量、川续断皂苷Ⅵ含量和水溶性浸出物为评价指标,采用正交设计法优选跌打促愈片的提取工艺。结果:丹酚酸B在0.37~2.96μg之间,线性关系良好,其回归方程为:Y=407.34 X-17.824,r=0.999 8;川续断皂苷Ⅵ在0.8~6.4μg之间,线性关系良好,其回归方程为:Y=255.94 X+5.095 1,r=0.999 5。跌打促愈片的最佳提取工艺为:浸泡2 h,加水煎煮2次,第1次加10倍量水提取1.5 h,第2次加8倍量水提取1.0h。结论:优选出的工艺可行,重复性好,可用于该制剂的提取。 Objective: To optimize the extraction process of the decoction. Methods: The salvianolic acid B content, Dictyosaponin Ⅵ content and water-soluble extract were used as evaluation indexes. The orthogonal design was adopted to optimize the extraction process of Dajian Yuyu tablets. Results: The linear range of salvianolic acid B was between 0.37 and 2.96 μg. The regression equation was: Y = 407.34 X-17.824, r = 0.999 8; Well, the regression equation is: Y = 255.94 X + 5.095 1, r = 0.999 5. The optimum extraction process of the drop-promoting tablet is as follows: soak for 2 h, add boiling water twice, add the first 10 times of water for 1.5 h and the second add 8 times of water for 1.0 h. Conclusion: The process is feasible and reproducible. It can be used for the extraction of this preparation.
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