2006年,新英格兰杂志刊载了一篇文章,描述了一种非经典的Ⅱ类主要组织相容性复合体分子(MHCⅡ类分子)限制性CD4+T细胞——恒定型自然杀伤细胞(iN KT细胞),Akbari等[1]表示过敏性哮喘患者肺内及肺泡灌洗液中主要的T细胞为iN KT细胞。从此,iN KT细胞在哮喘领域渐渐引起了人们的关注。尽管随着以后的研究进展,学者发现iN KT细胞具有有限的抗原特异性,并且仅能特 In 2006, the New England Journal published an article describing a nonclassical class II major histocompatibility complex molecule (MHC class II molecule) restricted CD4 + T cell-resident natural killer cells (iN KT Cells), Akbari et al [1] said that the main T cells in the lung and alveolar lavage fluid of patients with allergic asthma is iN KT cells. Since then, iN KT cells in the field of asthma gradually attracted the attention of people. Although with subsequent research advances, scholars found that iN KT cells have limited antigen specificity, and only special