宿主免疫功能在早发性牙周炎 (early -onsetperiodontitis,EOP)发病中的作用一直备受关注。近年许多研究发现EOP常呈家族性发病 ,且多数患者对细菌感染有异常的外周血中性粒细胞或单核细胞反应。但与疾病相关的宿主易感因素的研究仍众说纷纭 ,本文就影响EOP易感性的宿主遗传免疫特质的各方面研究进展进行综述 The role of host immune function in the pathogenesis of early-onset periodontitis (EOP) has been of great concern. In recent years, many studies have found that EOP often familial disease, and most patients with abnormal bacterial infection of peripheral blood neutrophils or monocytes response. However, there are still many controversies about the host susceptibility factors associated with the disease. This review summarizes the research advances in various aspects of host genetic immune traits that affect EOP susceptibility