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目的:测定国产左旋氯氟沙星胶囊po后在人体内的药物动力学.方法:10例健康志愿受试者,单次po国产左旋氯氟沙星胶囊,用反相高效液相色谱法测定血浆中药物浓度.结果:左旋氧氟沙星药物动力学参数分别为:C_(?)=(2.12±0.21)μg/ml,t_(?)=(1.16±0 18)h,T_(1/2α)=(1.50±0.65)H,T_(1/2β)=(6.16±1.15)h,CL=(16.27±2.15)L/h,V_d=(70.33±10.94)L,AUC_(0→∞)=(13.72±1.03)(Mg/L)·h.结论:国产左旋氧氟沙星胶囊的主要药物动力学参数与国外文献报道基本一致.
OBJECTIVE: To determine the pharmacokinetics of domestic levofloxacin capsule po in human.METHODS: A total of 10 healthy volunteers were given a single po of domestic levofloxacin capsules and determined by reversed-phase high performance liquid chromatography The pharmacokinetic parameters of levofloxacin were as follows: C_ (?) = (2.12 ± 0.21) μg / ml, t_ (?) = (1.16 ± 0 18) h and T_ (1 / 2α) = (1.50 ± 0.65) H, T 1 / 2β = 6.16 ± 1.15 h, CL = 16.27 ± 2.15 L / h, V_d = 70.33 ± 10.94 L, = (13.72 ± 1.03) (Mg / L) · h.Conclusion: The main pharmacokinetic parameters of domestic levofloxacin capsules are basically the same as those reported in foreign literature.