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目的通过对原发性肝细胞癌患者的血清中AFP、CA50、CA199进行联合检测,观察三者变化的的相关性。方法选择原发性肝细胞癌97例,进行血清AFPRIA、CA50RIA、CA199RIA的检测。结果与对照组相比,原发性肝细胞癌组的三项检测的结果明显高于对照组(p<0.01)。原发性肝细胞癌患者97例中血清AFP升高伴CA50、CA199升高的有89例,占总例数91.75%。结论对97例原发性肝细胞癌患者血清中AFP和CA50、CA199进行联合检测,发现三者的变化有显著的相关性,即血清中AFP水平升高时可伴有CA50和CA199水平的增高(91.75%),所以对原发性肝细胞癌患者检测AFP的同时也检测CA50、CA199,对诊断原发性肝细胞癌有一定的临床意义。
Objective To detect the correlation between the changes of AFP, CA50 and CA199 in the serum of patients with primary hepatocellular carcinoma. Methods 97 cases of primary hepatocellular carcinoma were selected for detection of serum AFPRIA, CA50RIA and CA199RIA. Results Compared with the control group, the results of the three tests in the primary hepatocellular carcinoma group were significantly higher than those in the control group (p <0.01). 97 cases of primary hepatocellular carcinoma in patients with elevated serum AFP with CA50, 89 cases of CA199 increased, the total number of 91.75%. Conclusions AFP, CA50 and CA199 in serum of 97 patients with primary hepatocellular carcinoma were detected. There was a significant correlation between the changes of the three, which means the level of serum AFP increased accompanied with the increase of CA50 and CA199 (91.75%), so the detection of AFP in patients with primary hepatocellular carcinoma also detected CA50, CA199, for the diagnosis of primary hepatocellular carcinoma has some clinical significance.