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因胃食管反流症状作内镜检查者中8％～20％发现有Barrett食管(BE)。有证据说明BE的特殊化上皮存在着进展到低度发育异常(dys)→高度dys→粘膜内癌→最后粘膜下癌的癌变顺序。每年每52～441例BE病人中发生1例腺癌。因此,建议BE病人定期进行内镜监测以发现早期、可治愈的肿瘤。但其费用昂贵,而不用内镜的气囊细胞学检查则费用低。本研究目的为确定盲目不经内镜导向的气囊细胞学检查在检出BE病人的dys及癌中所起的作用。
Barrett’s esophagus (BE) was found in 8% to 20% of patients who underwent endoscopy for gastroesophageal reflux symptoms. There is evidence that BE’s specialized epithelium has a cancerous sequence that progresses to low dysplasia (dys) → high dyss → intramucosal cancer → last submucosal cancer. One case of adenocarcinoma occurs every 52 to 441 cases of BE patients each year. Therefore, it is recommended that patients with BE have regular endoscopic surveillance to detect early, curable tumors. However, it is costly and does not require endoscopic balloon cytology to be inexpensive. The purpose of this study was to determine the role of blind, endoscopically-guided balloon cytology in the detection of Dys and cancer in BE patients.