经肾活检和临床资料确诊的LN患者 5 3例 ,采用免疫荧光双标记染色与低照度荧光图像分析检测方法 ,观察到LN患者肾组织中树突状细胞分布的面积、数量及密度均明显增多。树突状细胞主要分布于肾小管间质和肾血管 ,而肾小球基本未见分布。此外 ,树突状细胞在肾小管间质分布程度与肾小管间质病变程度及肾功能呈正相关。提示树突状细胞可能参与了狼疮性肾炎的发病机制 ,并与患者肾小管间质病变及肾功能密切相关 Fifty-three patients with LN confirmed by renal biopsy and clinical data were examined by immunofluorescence double staining and low-intensity fluorescence image analysis. The area, number and density of dendritic cells in LN were significantly increased . Dendritic cells are mainly located in the tubulointerstitium and renal vessels, while glomerular basically no distribution. In addition, the degree of dendritic cells in the distribution of tubulointerstitial tubulointerstitial lesions and renal function was positively correlated. Tip dendritic cells may be involved in the pathogenesis of lupus nephritis, and with tubulointerstitial lesions and renal function are closely related